Jeffrey James Weise (August 8, 1988 – March 21, 2005) was an Amerindian teenager who murdered nine people in a shooting spree on 21 March 2005 in Minnesota in an Amerindian reservation. He killed his grandfather and his grandfather's companion before going to the reservation high school, where he murdered seven more people and wounded five others. He committed suicide before being captured by the police.
Weise struggled in school due to frequent relocations, bullying, disruptions in his personal life and truancy. In May and June 2004, Weise tried twice to commit suicide and was briefly hospitalized. He was under treatment for depression, and had been prescribed Prozac as an anti-depressant. His case revived the public discussion about the use of Prozac for children and adolescents; the US Food and Drug Administration had published a warning about it in October 2004 as a factor in increased suicides and violence among youths.
Politically correct sources may also try to make associations with "White supremacism", despite Weise being Amerindian.