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Events of 1622
- January 1 – In the Gregorian calendar, January 1 is declared as the first day of the year, instead of March 25.
- February 8 – King James I of England disbands the English Parliament.
- March 12 – Ignatius of Loyola, Francis Xavier, Teresa of Avila, Isidore the Farmer and Philip Neri are canonized as saints by Pope Gregory XV.
- March 22 – Jamestown massacre: Algonquian natives kill 347 English settlers outside Jamestown, Virginia (1/3 of the colony's population) and burn the Henricus settlement.
- April 19 – Richelieu is made Cardinal.
- April 22 – Hormuz is captured from the Portuguese by an Anglo-Persian force.
- April 27 – Thirty Years' War: A Skirmish at Mingolsheim is fought between Protestant forces under Mansfeld and Georg Friedrich of Baden-Durlach, against Imperial forces under Tilly. The protestants win, but afterwards Tilly links up with a Spanish Army under Gonzalo de Córdoba, greatly increasing his strength.
- May – Huguenot rebellions: The huguenot city of Royan is taken by royal forces after a short siege.
- May 6 – Thirty Years' War: While waiting for the protestant forces of Christian of Brunswick to join them, Mansfeld and Georg Friedrich of Baden-Durlach split up their forces as a diversion for the Imperial army of Tilly. Their plan fails, as Tilly manages to cut off Georg Friedrich at Wimpfen. At the ensuing Battle of Wimpfen, Georg Friedrich's army is almost completely destroyed.
- May 13 – The Eendracht, a VOC ship and the second recorded European ship to make landfall on Australian soil, is wrecked off the western coast of Ambon Island, Dutch East Indies.
- May 20 – Ottoman Sultan Osman II is strangled by rebelling Janissaries, who revolted when they heard rumours that Osman II was planning to move against them.
- May 25 – The English ship Tryall, which left Plymouth, England for Batavia (now Jakarta), wrecks on the Tryal Rocks, 9 months later (wreck discovered in 1969).
- June 11 – Huguenot rebellions: The huguenot city of Nègrepelisse is taken after a short siege by royal forces. The entire population of the city is subsequently massacred, and the city is burned to the ground.
- June 20 – Thirty Years' War: Imperial forces under Tilly attempt to prevent Christian of Brunswick from moving his army across the Main river to link up with Mansfeld. At the Battle of Höchst, Tilly manages to inflict considerable casualties on the protestant forces, as well as seizing Brunswick's baggage train. Nonetheless, the bulk of Brunswick's forces manage to unite with Mansfeld.
- July 13 – Thirty Years' War: After Mansfeld fails to relieve the siege of Heidelberg, Frederick V, Elector Palatine, cancels Mansfeld's contract and disbands his army. The unemployed army of Mansfeld and Christian of Brunswick is subsequently hired by the Dutch.
- July 13/14 – English and Dutch ships defeat the Portuguese near Mozambique.
- July 18 – Eighty Years' War: Bergen-op-Zoom is besieged by a Spanish army under the command of Ambrogio Spinola.
- August 29 – Thirty Years' War: While on their way to relieve the Siege of Bergen-op-Zoom in the Netherlands, the army of Mansfeld and Christian of Brunswick is blocked by a Spanish army led by Gonzalo de Córdoba. In the Battle of Fleurus, Cordoba manages to fight off the protestant assault. The next day, Cordoba surprises the retreating protestant army with his cavalry, resulting in the destruction of most of the protestant army.
- September 19 – Thirty Year's War: Heidelberg, the capital of the Electoral Palatinate, is taken by the Imperial army of Tilly after a three-month siege.
- October 2 – Eighty Years' War: After a siege of 86 days, Bergen-op-Zoom is relieved by a Dutch army led by Maurice of Nassau and Ernst von Mansfeld.
- October 18 – Huguenot rebellions: The first Huguenot rebellion ends with the signing of the Treaty of Montpellier.
- October 27 – Huguenot rebellions: The inconclusive Naval battle of Saint-Martin-de-Ré is fought between the Huguenot fleet of La Rochelle commanded by Jean Guiton, and a royal fleet under the command of Charles of Guise.
- Dutch ships under Joachim Swartenhondt, while escorting a convoy, repel a Spanish squadron near Gibraltar.
- Étienne Brûlé is the first European to see Lake Superior.
- Portugal loses control of the island of Ormus, after 107 years.
- Albertus Magnus is beatified, and Teresa of Avila is canonized, by the Roman Catholic Church.
- Spanish galleon Nuestra Señora de Atocha sinks off the Florida Keys, while carrying copper, 35 tons of silver, 161 pieces of gold, tobacco, and indigo (Wreck discovered 1985).
- Philip IV of Spain starts to rule.
- War between the Netherlands and Spain recommences after the Twelve Years' Truce (1609–1621).
- First record of Bottled Spring Water in UK at Holy Well Spring, Malvern 1622